Anxiolytic effects of the melatonin MT2 receptor partial agonist UCM765: Comparison with melatonin and diazepam
Melatonin (MLT) is a neurohormone known to be involved in the regulation of anxiety. Most
of the physiological actions of MLT in the brain are mediated by two high-affinity G-protein-
coupled receptors, denoted MT1 and MT2. However, the particular role of these receptors in
anxiety remains to be defined. Here we used a novel MT2-selective partial agonist, UCM765
to evaluate the involvement of MT2 receptors in anxiety. Adult male rats were acutely
injected with UCM765 (5–10–20mg/kg), MLT (20mg/kg) or diazepam (DZ, 1mg/kg). Anxiety …
of the physiological actions of MLT in the brain are mediated by two high-affinity G-protein-
coupled receptors, denoted MT1 and MT2. However, the particular role of these receptors in
anxiety remains to be defined. Here we used a novel MT2-selective partial agonist, UCM765
to evaluate the involvement of MT2 receptors in anxiety. Adult male rats were acutely
injected with UCM765 (5–10–20mg/kg), MLT (20mg/kg) or diazepam (DZ, 1mg/kg). Anxiety …
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